OTT has developed several model license agreements that serve as the basis for license negotiation. The business development plan submitted as part of the license application process serves as the basis for establishing performance benchmarks that are included in the license agreement. OTT works closely with licensees to monitor performance and to adjust benchmarks, when appropriate, to ensure the successful commercial development of its inventions.

Licensees are required to respond at least annually on their utilization of or efforts to utilize license patent rights. These responses are kept confidential and, to the extent permitted by law, are exempt from disclosure under the Freedom of Information Act (5 U.S.C. §552).

Licenses are revocable for specific reasons, such as non-use of or failure to develop the invention, failure to comply with governing regulations, or failure to satisfy public health needs. Licensees also must normally agree that any products embodying the invention or made through the use of the invention, and which are sold in the United States will be manufactured in the United States.