This technology describes immortalized human umbilical cord-blood T lymphocytes transformed with the retrovirus human T-cell leukemia-lymphoma virus (HTLV). These cells contain the HTLV genome and synthesize viral RNA but are restricted in their expression of viral structure proteins. This cell line should be useful in the study of retrovirus expression. Please visit the NIH AIDS Research and Reference Reagent Program website (www.aidsreagent.org; catalog #404) for additional information.
Applications:
Viral expression studies
Study of viral proteins and nucleic acids involved in T-cell immortalization
SZ Salahuddin et al. Restricted expression of human T-cell leukemia--lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes. Virology 1983 Aug;129(1):51-64. [PubMed abs]
NIH AIDS Research and Reference Reagent Program website (www.aidsreagent.org)
Patent Status:
DHHS Reference No. E-272-2007/0 – Research Tool
Patent protection is not being sought for this technology.
Licensing Status:
Available for licensing
Portfolio:
Research Materials
For additional information, please contact:
Susan Ano, Ph.D.
Office of Technology Transfer
National Institutes of Health
6011 Executive Boulevard, Suite 325
Rockville MD 20852
Phone: 301/435-5515
Fax: 301/402-0220
Email: anos@mail.nih.gov
