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Internal Medicine - Therapeutics:

DateRef. No.Patent No.Title
11/10/2009E-192-2008/1Optimized Expression of IL-12 Cytokine Family
11/4/2009E-273-2009/0Simpler is Better: The Production of Young Cell Cultures from Tumor Infiltrating Lymphocytes (TIL) Yields More Effective Adoptive Cell Transfer (ACT) Immunotherapies
11/4/2009E-158-2003/1New Derivative of Dextromethorphan for Use in Neuronal Therapy
10/12/2009E-255-2007/0A Target for the Development of Diagnostics and Therapeutics for Abnormal Hematopoiesis
10/10/2009E-134-2009/0Engineered Biological Pacemakers
10/7/2009E-147-1999/0
E-147-1999/1
6,977,245Oligodeoxynucleotide and Its Use To Induce an Immune Response
9/21/2009E-009-2009/0Treatment of Airway Diseases, Including Asthma and COPD, by Targeting Airway Hyperresponsiveness
9/2/2009E-068-2007/0Novel Roles of a DNA Repair Protein, DNA-PKcs, in Obesity, Neurological Function, and Aging
9/2/2009E-018-2009/0Biomarkers for Sjögren's Syndrome
7/29/2009E-285-2008/0Truncated Methanocarba Adenosine Derivatives as A3 Adenosine Receptor Antagonists
7/29/2009E-138-2008/0Non Toxic Peptide Treatment for Dyslipidemic and Vascular Disorders
7/29/2009E-040-2004/07,504,243High-yield Methods of Producing Biliverdin
7/3/2009E-002-2008/0Modulators of Pregnane X Receptor (PXR) as Therapeutics for Bowel Disorders (BD)
7/2/2009E-196-2004/0Bone Morphogenetic Variants, Compositions and Methods of Treatment
7/2/2009E-127-1995/0
E-127-1995/1
E-127-1995/2
E-138-1994/0
E-196-2004/0
6,884,871
6,924,367
7,049,291
7,148,036
7,220,558
7,563,596
Novel Osteobiologic Proteins for Treatment of Osteoporosis, Rheumatoid and Neurologic Diseases
7/2/2009E-033-2008/0Therapeutic Applications of a p53 Isoform in Regenerative Medicine, Aging, and Cancer
7/2/2009E-127-1995/0
E-127-1995/1
E-127-1995/2
6,884,871
6,924,367
7,049,291
7,563,596
Isolation And Use Of Tissue Growth-Inducing FRZB Protein
6/11/2009E-164-2007/0Compounds Binding to the N-Terminal Domains of STAT Proteins as Therapeutic Agents
5/15/2009E-025-1998/06,610,684Fused Azepinone Cyclin Dependent Kinase Inhibitors
5/5/2009E-084-2009/0Genetic Mutations Associated with Stuttering
5/5/2009E-338-2005/0Novel Inhibitors of Bone Morphogenetic Proteins
5/4/2009E-223-2006/1
E-284-2008/0
Small-Molecule TSH Receptor Modulators for Diagnosis and Treatment of Thyroid Disease and Cancer
5/4/2009E-003-2000/07,135,303Discovery of a Novel Human Aminopeptidase Which May Regulate Cleavage and Shedding of the Human Type-I Tumor Necrosis Factor Receptor
5/4/2009E-193-1997/06,555,367Targeted Recombinant Adenoviral Vectors
3/25/2009E-312-2008/0Cell Based Immunotherapy
3/23/2009E-219-2007/0
E-219-2007/2
Dendrimer Conjugates Targeting Adenosine Receptors, P2Y Receptors and Other Receptors of the GPCR Superfamily, for Use in the Treatment of Various Disorders, Including Neurodegenerative Diseases, Stroke, Epilepsy, Pain and Thrombosis
11/1/2008E-250-2007/0Induced Internalization of Surface Receptors
11/1/2008E-187-2007/0Indoline Compounds for the Treatment of Spinal Muscular Atrophy (SMA) and Other Diseases
11/1/2008E-256-1999/0Methods for Accurately Measuring and Regulating Bound Adrenomedullin
9/1/2008E-104-1997/06,828,309Use of Pentosan Polysulfate to Treat Certain Conditions of the Prostate
8/1/2008E-140-2008/0Species-Independent A3 Adenosine Receptor Agonists
8/1/2008E-227-2006/5Methods of Preventing Tissue Ischemia
7/1/2008E-233-2007/0Tendon Stem Cells
7/1/2008E-211-2006/0Therapeutic Application of Fatty Acid Amide Hydrolase Inhibitors
7/1/2008E-229-2006/0Novel O-GLcNAcase Inhibitor and Fluorogenic Substrate as a Tool for Diagnosing Type 2 Diabetes
7/1/2008E-154-2006/0Use of Human Gamma Satellite Insulator Sequences to Prevent Gene Silencing and Allow for Long Term Expression of Integrated Transgenes
7/1/2008E-181-1997/06,479,286Methods and Compositions for Making Dendritic Cells from Expanded Populations of Monocytes and for Activating T Cells
7/1/2008E-321-2006/0Treatment of Skin Conditions Using DKK1
5/1/2008E-096-2000/07,531,352The Use of an Inducible Plasmid Vector Encoding for Active TGF-beta for the Treatment of Autoimmune Diseases
5/1/2008E-120-2003/27,378,276Method of Inducing Memory B Cell Development and Terminal Differentiation
5/1/2008E-286-2006/2A Novel Growth Factor and Anti-Apoptotic Agent for Promoting Lung Development and Treating Lung Disease
5/1/2008E-129-2008/0Synthetic Analogs of Juxtamembrane Domain of IGF-1 Receptor as Anti-Cancer Agents
5/1/2008E-110-2006/0Muramyl Dipeptide as a Therapeutic Agent for Inflammation
5/1/2008E-206-1995/36,320,022
7,101,548
Treatment and Diagnosis of Cancer, Diabetes and other Disorders Using Adrenomedullin Peptides and Antibodies
3/1/2008E-154-2007/0VEGF-B as a Therapeutic Agent for Neurodegenerative Disease
3/1/2008E-217-2007/0N-Acetyl Mannosamine as a Therapeutic Agent
2/1/2008E-172-2007/2Collagen-Induced Platelet Aggregation Inhibitor from Mosquito Salivary Glands
2/1/2008E-203-2000/07,144,918Biologically Active Macrolides, Compositions and Uses Thereof
2/1/2008E-069-2000/2
E-069-2000/3
7,196,074Preparation and Use of Androgenic Compounds
1/1/2008E-108-2007/0Photosensitization by Nuclear Receptor-Ligand Complexes and Cell Ablation Uses Thereof
12/1/2007E-168-2007/0Treatment for Chronic Inflammatory Disease and Cancer by Inhibition of MMP-1
10/1/2007E-064-2005/0Biomarkers for Tissue Status
9/1/2007E-174-2007/0Suppression of Allergic Asthma by Ascaris Antigens
8/1/2007E-138-1992/15,877,179Treatment for Cystic Fibrosis Cells and Other Reduced Cl- Conductance Cells
8/1/2007E-068-1998/06,685,933
7,235,232
Interferon Alpha Hybrids
8/1/2007E-282-2002/0Methods and Compositions for Treating Diseases and Disorders Associated with Natural Killer T-Cells
7/1/2007E-089-2005/0Benztropinamine Analogs as Dopamine Transport Inhibitors
7/1/2007E-149-2005/0Methods and Materials for Identifying Polymorphic Variants, Diagnosing Susceptibilities, and Treating Disease
7/1/2007E-059-2006/0Method of Treating or Preventing Oxidative Stress-related Diseases (stroke and neurodegenerative diseases, wound healing and cardiovascular diseases)
6/1/2007E-012-1991/0
E-012-1991/2
E-044-1997/0
E-044-1997/1
5,167,956
5,725,857
6,632,928
Immunotoxin with in-vivo T cell Suppressant Activity
6/1/2007E-088-2007/0Zscan4: A Gene Critical for Early Embryonic Development
6/1/2007E-012-1991/0
E-012-1991/4
E-012-1991/7
E-044-1997/0
E-044-1997/1
E-059-1998/0
E-168-1999/0
5,167,956
5,762,927
6,103,235
6,632,928
7,288,254
Methods of Inducing Immune Tolerance Using Immunotoxins
6/1/2007E-137-1993/05,554,603Orally Active Derivatives of 1,3,5(10)-estratriene
5/1/2007E-056-2004/0STAMP, A Novel Cofactor and Possible Steroid Sparing Agent, Modulates Steroid-induced Induction or Repression of Steroid Receptors
5/1/2007E-140-2006/0A Fullerene-based Anticoagulant
5/1/2007E-168-2001/0
E-168-2001/1
7,192,705TMC1, a Deafness-Related Gene
5/1/2007E-281-2002/07,193,053Leu574 of HIF-1alpha as a Molecular Basis for Therapeutic Application
4/1/2007E-181-2004/0Preparation and Use of Androgenic Compounds: Nandrolone 17beta-carbonates
4/1/2007E-205-2006/2Preparation of (R,R)-Fenoterol and (R,R)-or (R,S)-Fenoterol Analogues and Their Use in Treating Congestive Heart Failure
4/1/2007E-011-2007/0Methods for Treating Autoimmune Inflammatory Disease by Blocking DR3-TL1A Interactions
4/1/2007E-103-2000/0
E-103-2000/1
E-103-2000/2
E-305-2005/0
6,753,317
6,916,905
Novel Dmt-Tic Analogues Specific for Delta- and Mu-Opioid Receptors
4/1/2007E-014-2002/0Neural Crest-Melanocyte cDNA Based Microarray Analysis for Human Skin Pigmentation Research
1/1/2007E-234-2005/1Novel Benztropine Analogs for Treatment of Cocaine Abuse and Other Mental Disorders
1/1/2007E-201-1989/05,420,033Epithelial Cell Line Expressing a Cystic Fibrosis Phenotype
12/1/2006E-347-2004/0ARH3, a Therapeutic Target for Cancer, Ischemia, and Inflammation
12/1/2006E-014-2007/0Peptide and Peptidomimetic Inhibitors of Smoothened Protein as Anti-neoplastic Agents
11/1/2006E-186-2006/0Second Generation Nitric Oxide-releasing Non-steroidal Anti-inflammatory Drugs Possessing a Diazeniumdiolate Group (NONO-NSAIDs)
9/1/2006E-007-1996/06,635,614
728257
Use of LCAT to Reduce Cholesterol and Prevent Atherosclerosis
9/1/2006E-262-2003/0Methods for Enhancing Beta Cell Function in Diabetes
8/1/2006E-042-2006/0Complement Regulatory Gene Variants as Predictive Tests for Age-related Macular Degeneration (AMD)
8/1/2006E-336-2001/0Amyloid Beta is a Ligand for FPR Class Receptors
7/1/2006E-017-2004/0Methods and Compositions Related to GHS-R Antagonist
6/1/2006E-108-2005/0Treatment of Inflammatory Bowel Disease (IBD) using NF-KB Decoy Polynucleotides
6/1/2006E-003-2005/0Treatment and Prevention of Inflammatory Bowel Disease (IBD) using Mutant and Chimeric IL-13 Molecules
5/1/2006E-055-1999/06,680,176Identification of Candidate Ligands which Modulate Antigen Presenting Cells
5/1/2006E-075-2003/0Use of Cripto-1 as a Biomarker for Neurodegenerative Disease and Method of Inhibiting Progression Thereof
3/1/2006E-263-2003/0Immunogenic T Cell Targets in Autoimmune Hepatitis and Methods of Use
3/1/2006E-262-1999/17,459,536Monoclonal Antibodies Which Specifically Bind to the Ligand Hepatocyte Growth Factor (HGF) and are Useful in the Treatment of Cancer
3/1/2006E-208-2003/0TNF-alpha Converting Enzyme Inhibitory Agents and Stimulatory Agents
9/1/2005E-009-1991/0
E-009-1991/1
E-301-1998/2
5,217,953
5,565,424
Cancer Therapy Using Vasoactive Intestinal Peptide Antagonists
9/1/2005E-105-2002/0Regulation of INS (3456) P4 Signaling by a Reversible Kinase/Phosphatase and Methods and Compositions Related Thereto
8/1/2005E-092-2004/0Anti-Marinobufagenin Antibodies and Methods for Their Use
7/1/2005E-033-2004/0Multipotent Postnatal Stem Cells From Human Periodontal Ligament and Uses Thereof
6/1/2005E-188-2004/0Therapeutic Delivery of Nitric Oxide From Novel Diazeniumdiolated Derivatives of Acrylonitrile-based Polymers
5/1/2005E-199-1999/0Mycolactone and Related Compounds
4/1/2005E-318-2004/0Regulation of ATG7 Beclin 1 Program of Autophagic Cell Death by Caspase-8
4/1/2005E-070-1982/25,656,587
5,705,477
Compositions of Transforming Growth Factor Beta (TGF-beta) Which Promotes Wound Healing and Methods for Their Use
4/1/2005E-252-1999/06,916,843Endothelial Protective Actions of Cytochrome P450 Epoxygenase-derived Eicosanoids
3/1/2005E-010-2004/2Modulating P38 Kinase Activity
2/1/2005E-328-2004/0Methods for Treating Active Uveitis
2/1/2005E-248-2004/0A3 Adenosine Receptor Agonists
2/1/2005E-355-2004/0Compositions and Methods for the Treatment of Immune-Related Disease
2/1/2005E-094-2003/0A Novel, Preservative-Free Steroid Formulation for Use as an Anti-Inflammatory
1/1/2005E-130-2004/0Novel Methods for Reducing Inflammation and Treating Diseases such as Parkinson’s and Alzheimer’s Disease
1/1/2005E-244-2004/0The UBE2G2 Binding Domain in the Ubiquitin Ligase GP78 and Methods of Use Thereof
1/1/2005E-259-2003/0Anti-Proliferative Activity of an Unexpected mTOR Kinase Inhibitor
1/1/2005E-131-2002/0A Method of Treating Inflammatory Bowel Disease (IBD)
1/1/2005E-102-2004/0Treatment of Inappropriate Immune Responses
1/1/2005E-208-2002/0Applications for the HMGN1 Pathway
12/1/2004E-332-2004/0The Use of Rabbits with Defined Immunoglobulin Light Chain Genes (Ckappa b allotypes) to Optimize Production of Chimeric and Humanized Monoclonal Antibodies for Therapeutic, Imaging and Diagnostic Applications
12/1/2004E-072-2000/06,855,314AAV5 Vector for Transducing Brain Cells and Lung Cells
12/1/2004E-204-1999/07,238,473TTP as a Regulator of GM-CSF mRNA Deadenylation and Stability
8/1/2004E-211-2003/0A Combined Immunosuppressive Therapy Consisting of Glucocorticoid and rIL-2
6/1/2004E-016-2004/0Methods for Inhibiting Proinflammatory Cytokine Expression Using Ghrelin
5/1/2004E-211-2002/0
E-211-2002/1
7,332,645IL-21 Critically Regulates Immunoglobulin Production
4/1/2004E-048-2004/2Construction of a Recombinant Mammalian Expression System for the Production of Human TGF-beta 1 and Members of TGF-beta Superfamily Cytokines
2/1/2004E-151-1992/05,935,575Interleukin-4 Stimulated T-Lymphocyte Cell Death for the Treatment of Autoimmune Diseases, Allergic Disorders and Graft Rejection
2/1/2004E-137-1991/05,989,546
6,083,503
Interleukin-2 Stimulated T-Lymphocyte Cell Death for the Treatment of Autoimmune Diseases, Allergic Disorders and Graft Rejection
2/1/2004E-286-2002/0
E-286-2002/1
E-286-2002/2
Aerosolized Capreomycin for Inhibition of Pulmonary Tuberculosis
12/1/2003E-081-2002/0A Mouse Model for Human Osteoarthritis
11/1/2003E-223-2002/0Factors That Bind Intestinal Toxins
10/1/2003E-001-2003/0
E-001-2003/1
E-019-2003/0
Methods and Materials for Controlling Stem Cell and Cancer Cell Proliferation and Differentiation
10/1/2003E-294-2002/07,462,593A New Target for Angiogenesis and Anti-Angiogenesis Therapy
8/1/2003E-329-2001/07,220,582Stem Cells that Transform to Beating Cardiomyocytes
8/1/2003E-301-2002/0Cycloxygenase Inhibition with Nitroxyl
8/1/2003E-273-2002/06,936,639Nitroxyl Progenitors in the Treatment of Heart Failure
8/1/2003E-293-2002/07,364,719Vasopressor Peptide Derived From Adrenomedullin and Methods of Its Use
8/1/2003E-143-2002/0
E-143-2002/1
7,258,859
7,575,742
Method for the Treatment of Multiple Sclerosis
7/1/2003E-281-2001/07,220,718Oral Treatment of Hemophilia
6/1/2003E-113-2002/0Method for Preparing 17alpha-acetoxy-11beta-(4,N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, Intermediates Thereof, and Methods for the Preparation of Such Intermediates
5/1/2003E-097-2003/0Triggering Receptors Expressed in Myeloid Cells (TREM) Like Transcript (TLT-1), A Novel Inhibitory Receptor of Platelets and Uses Therefore
5/1/2003E-076-2003/0
E-175-2002/0
Method of Treating Ischemia/Reperfusion Injury with Nitroxyl Anion Donors
5/1/2003E-149-2001/0
E-276-2002/0
6,673,338
6,949,530
7,105,502
7,348,319
Preparation and Medical Uses of Novel Nitric Oxide Releasing Imidates, Amidines Derived Therefrom, and Enamines
5/1/2003E-176-1999/07,087,589Methanocarba Cycloalkyl Nucleoside Analogues
4/1/2003E-060-2000/0
E-060-2000/1
4248600
7,488,710
sFRP and Peptide Motifs That Interact with sFRP and Methods of Their Use
3/1/2003E-261-2000/07,375,185Optimization of Cardiac Contraction by Novel Human Kinase Mediated Differential Phosphorylation of Myosin
3/1/2003E-189-2002/07,468,435Novel Cyclic Polyamines That Release Nitric Oxide in a Biphasic Manner
3/1/2003E-185-1997/26,368,828Attenuated and Dominant Negative Variant cDNAs of STAT6: STAT6b and STAT6c
11/1/2002E-080-2002/07,511,015Modified Defensins and Their Use
11/1/2002E-296-2001/07,541,040Alleviating Symptoms of Th2-Like Cytokine Mediated Disorders by Reducing IL-13 Receptor-Expressing Cells in the Respiratory Tract
8/1/2002E-053-2002/07,563,766Methods and Compositions for the Promotion of Hair Growth Utilizing Actin-Binding Peptides
5/1/2002E-113-1999/0Sol Fusin: Use of GP64-6HIS to Catalyze Membrane Fusion
3/1/2002E-360-2001/0Generation and Use of Tc1 and Tc2 Cells
9/1/2001E-067-2001/0Secretion of Native Recombinant Lysosomal Enzymes by Liver
4/1/2001E-237-1999/07,261,896Methods for Preventing Strokes by Inducing Tolerance to E-selectin
2/1/2001E-015-2000/0Antiprogestins with Partial Agonist Activity
12/1/2000E-123-1999/07,122,624PTH2 and PTH1 Receptor Ligands
9/1/2000E-061-1999/0Polypeptides Comprising IL-6 Ligand Binding Receptor Domains and Related Nucleic Acids, Antibodies, Compositions and Methods
8/1/2000E-041-2000/06,448,245HIV Protease Inhibitors, Ritonavir and Saquinavir are Potent Inhibitors of Calcium Activated Neutral Peptidases, Calpains
8/1/2000E-149-1999/06,852,686Ichthyosiform Skin Diseases
4/1/2000E-257-1999/0Methods and Compositions for Correlating CCR5 Expression with Essential Hypertension
8/1/1999E-045-1994/0
E-045-1994/1
5,587,309
5,888,705
Methods of Stimulating Proliferation and Differentiation of Human Pancreatic Cells Ex Vivo
8/1/1999E-169-1999/07,129,052Peptides and Their Utility in Modulation of Behavior of Cells Expressing alpha3beta1 Integrins
7/1/1999E-127-1996/05,998,598Immunoadhesins and Methods of Production Thereof
7/1/1999E-200-1997/06,479,465Methods of Treating Colitis Using STAT-4 Antisense Oligonucleotide
6/1/1999E-093-1996/0
E-093-1996/1
E-093-1996/2
E-093-1996/3
6,610,660
6,911,433
7,081,524
O2-Arylated or O2-Glycosylated 1-Substituted Diazen-1-ium-1,2-diolates and O2-Substituted 1-[(2-Carboxylato)Pyrolidin-1-yl] Diazen-1-ium-1,2-diolates
6/1/1999E-282-1998/0Antagonists of the Alpha Epsilon Beta 7 Integrin as Therapeutic Agents for Inflammatory Diseases
2/1/1999E-163-1996/06,458,590Methods and Compositions for Treatment of Restenosis
12/1/1998E-137-1996/06,326,466Double-Stranded RNA Dependent Protein Kinase Derived Peptides To Promote Proliferation Of Cells And Tissues In A Controlled Manner
11/1/1998E-182-1997/06,562,859Ureido Derivatives Of Poly-4-Amino-2-Carboxy-1-Methyl Pyrrole Compounds For Treatment Of Inflammation
10/1/1998E-009-1996/06,365,712
6,846,911
Methods And Compositions For Inhibiting Inflammation And Angiogenesis
9/1/1998E-153-1997/06,084,063Signal Transduction Inhibitors Of Allergic Reactions
9/1/1998E-166-1998/07,504,096LIF And Related Cytokines That Operate Through The gp130 Receptor Pathway As A Means To Enhancing Embryo Implantation In Mammals And As An Alternative To Using Estrogen
1/1/1998E-159-1996/0Formation Of Human Bone In Vivo
11/1/1997E-257-1997/06,627,745Identification Of The Gene Causing Familial Mediterranean Fever
5/1/1997E-090-1991/05,328,990
5,656,737
Macrophage Migration Inhibitory Factor (MIF)
4/1/1997E-139-1994/05,637,323Method Of Mobilizing Pluripotent Hematopoietic Stem Cells And Accelerating Leukocyte Reconstitution With IL-7
1/1/1997E-132-1996/06,780,413Immunotoxin (MAB-RICIN) For The Treatment Of Focal Movement Disorders
12/1/1996E-184-1995/0
E-184-1995/1
Materials And Methods For Detection And Treatment Of Insulin Dependent Diabetes
7/1/1996E-083-1990/05,219,991
5,527,685
Macrophage Stimulating Protein
7/1/1996E-097-1995/05,853,697Methods Of Treating Established Colitis Using Antibodies Against IL-12
7/1/1996E-002-1986/05,352,77275 Kilodalton Interleukin-2 Receptor Proteins And Their Use
4/1/1996E-001-1989/05,532,144
6,090,795
Human Derived Monocyte Attracting Purified Peptide Products For Treating Human Infection And Neoplasms
4/1/1996E-176-1995/06,265,160Method Of Identifying Inhibitors Of The Jak-STAT Signal Transduction Pathway
2/1/1996E-068-1993/05,556,754
5,871,950
Methods For Treating Autoimmune Diseases And Transplantation Rejection
2/1/1996E-263-1988/05,585,346Peptide Derivatives Of Cytochrome b558 And Their Use As Medicaments [As Anti-Inflammatory Agents]
11/1/1993E-079-1993/0
E-079-1993/1
5,518,880
5,912,173
Methods for Diagnoses and Treatment of XSCID
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