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Gene Based Therapies - Therapeutics:

DateRef. No.Patent No.Title
10/28/2009E-296-2009/0Novel Inhibitors of Interleukin-6 for Kaposi Sarcoma Therapy
9/3/2009E-169-2004/0
E-281-2005/0
E-318-2000/0
Rapid Diagnostic Applications of Phage
8/5/2009E-184-2001/17,271,150Modified Growth Hormone
7/2/2009E-196-2004/0Bone Morphogenetic Variants, Compositions and Methods of Treatment
7/2/2009E-127-1995/0
E-127-1995/1
E-127-1995/2
E-138-1994/0
E-196-2004/0
6,884,871
6,924,367
7,049,291
7,148,036
7,220,558
7,563,596
Novel Osteobiologic Proteins for Treatment of Osteoporosis, Rheumatoid and Neurologic Diseases
5/28/2009E-043-2009/0T Cells Attacking Cancer: T Cell Receptors that Recognize the Tyrosinase Tumor Antigen
5/5/2009E-092-2008/0Novel Oligonucleotides for Treatment of Human Cancer
5/4/2009E-223-2003/1Improved Expression Vectors for Mammalian Use
1/9/2009E-278-2007/0Attenuated Salmonella as a Delivery System for siRNA-Based Tumor Therapy
1/1/2009E-051-2008/0A Novel and Efficient Technology for Targeted Delivery of siRNA
11/1/2008E-308-2001/07,419,817Scalable Purification of AAV2, AAV4 or AAV5 Using Ion-Exchange Chromatography
11/1/2008E-174-2008/0Therapeutic Targeting of CSN5, a Negative Regulator of p53 and p27, in Human Hepatocellular Carcinoma
7/1/2008E-154-2006/0Use of Human Gamma Satellite Insulator Sequences to Prevent Gene Silencing and Allow for Long Term Expression of Integrated Transgenes
5/1/2008E-096-2000/07,531,352The Use of an Inducible Plasmid Vector Encoding for Active TGF-beta for the Treatment of Autoimmune Diseases
2/1/2008E-069-2000/2
E-069-2000/3
7,196,074Preparation and Use of Androgenic Compounds
11/1/2007E-061-2007/0Diagnostic Ovarian Cancer Biomarkers
8/1/2007E-179-2005/0Isolation, Cloning and Characterization of New Adeno-Associated Virus (AAV) Serotypes
8/1/2007E-104-2006/0Immunogenic Peptides and Methods of Use for Treating Prostrate and Uterine Cancers
8/1/2007E-215-2007/0Methods for Determining Hepatocellular Carcinoma Subtype and Detecting Hepatic Cancer Stem Cells
7/1/2007E-118-2005/0A Gene Therapy to Treat Lung Cancer
6/1/2007E-042-1998/06,897,018
7,534,565
DLC-1 Gene Deleted in Cancers
6/1/2007E-310-2001/0Identification of Ovarian Cancer Tumor Markers and Therapeutic Agents
3/1/2007E-105-2003/0Cloning and Characterization of an Avian Adeno-Associated Virus and Uses Thereof
2/1/2007E-231-1998/06,790,657
7,226,780
Lentivirus Vector System
5/1/2006E-200-2005/0Insect Cell Production of Recombinant Adeno-Associated Virus that Produce Cytotoxic Gene Products and Applications for Solid Tumor Therapy
5/1/2006E-090-2006/0Adoptive Immunotherapy with Autologous Natural Killer Cells
5/1/2006E-176-1998/1Anti-Notch-1 Monoclonal Antibodies for Inducing Cellular Differentiation and Apoptosis
3/1/2006E-045-1995/06,984,379Gene Therapy by Administration of Genetically Engineered CD34+ Obtained by Cord Blood
3/1/2006E-128-2005/0Rapid Methods for Human Artificial Chromosome (HAC) Formation
1/1/2006E-298-2004/0Transcytosis of Adeno-Associated Viruses
10/1/2005E-127-1998/06,984,517
7,479,554
AAV5 Vector and Uses Thereof
6/1/2005E-138-2005/0Infectious Particle Composition and Methods of Use Thereof
3/1/2005E-281-1999/07,087,736Tyrosyl-DNA Phosphodiesterases (TDP) and Related Polypeptides, Nucleic Acids, Vectors, TDP-Producing Host Cell, Antibodies and Methods of Use
2/1/2005E-204-2001/07,314,712Rapid, Efficient In Vivo Site-Directed Mutagenesis Using Oligonucleotides
11/1/2004E-233-2004/0
E-233-2004/1
Anti-HIV Peptide Secreting Bacteria: Therapeutics and Methods of Use
11/1/2004E-178-2004/07,598,071Infectious Clone of Human Parvovirus B19 and Methods of Use
9/1/2004E-312-2000/07,226,779Hybrid Adeno-Retroviral Vector for the Transformation of Cells (E-312-2000)
8/1/2004E-040-1996/06,734,014
7,378,277
Methods and Compositions for Transforming Dendritic Cells and Activating T Cells
8/1/2004E-325-2001/1
E-325-2001/2
6,723,551
7,271,002
Production of Adeno-Associated Viruses in Insect Cells
4/1/2004E-073-2004/0Reduction of HIV-1 Replication by a Mutant Apolipoprotein B mRNA Editing Enzyme-Catalytic Polypeptide-like 3G (APOBEC3G)
4/1/2004E-326-2002/0
E-326-2002/2
Triplex Hairpin Ribozyme
4/1/2004E-258-1998/07,052,904
7,618,623
Hybrid Adeno-Retroviral Vector for the Transformation of Cells (E-258-1998)
2/1/2004E-006-1991/1
E-139-1995/0
E-166-1995/0
E-196-1993/0
5,460,941
5,510,473
5,707,811
5,731,411
Homologous DNA Recombination
12/1/2003E-191-2001/0gp64 Pseudotyped Vectors and Uses Thereof
11/1/2003E-038-2003/0High Efficiency Single Stranded Homologous Recombination in Host Cells Deficient for Mismatch Repair
11/1/2003E-008-2001/07,598,077Compositions and Methods for Enhancing Differential Gene Expression
10/1/2003E-001-2003/0
E-001-2003/1
E-019-2003/0
Methods and Materials for Controlling Stem Cell and Cancer Cell Proliferation and Differentiation
8/1/2002E-165-2001/0Maxp1, A New Tumor Suppressor Regulated by Ras
5/1/2002E-284-2001/0Specific Inhibition of Gene Expression by Small Double Stranded RNAs
5/1/2002E-206-2000/0
E-206-2000/1
Enhanced Distribution of Therapeutic Agents After Local Delivery
3/1/2002E-253-2000/0Artificial Chromosomes That Can Shuttle Between Bacteria, Yeast, and Mammalian Cells
8/1/2001E-264-2001/0H2,056A Mouse Model of von Hippel-Lindau Disease
4/1/2001E-088-1999/06,949,624Cloning of the Human Nuclear Receptor Co-Repressor Gene
2/1/2001E-174-1998/06,974,698Methods for Delivering Biologically Active Molecules into Cells
12/1/2000E-170-2000/07,141,661NAG-1: A Non-Steroidal Anti-Inflammatory Drug Related Gene Which Has Anti-Tumorigenic Properties
11/1/2000E-177-2000/27,144,734Enhanced Homologous Recombination Mediated by Lambda Recombination Proteins
7/1/2000E-087-2000/07,358,090Establishment of Cellular Manipulations Which Enhance Oligo-Mediated Gene Targeting
4/1/2000E-194-1998/06,441,156
6,979,724
Calcium Channel Compositions and Methods of Use Thereof
9/1/1999E-059-1996/06,686,333Inhibition of HIV Replication Using Soluble Tat Peptide Analogs
7/1/1999E-200-1997/06,479,465Methods of Treating Colitis Using STAT-4 Antisense Oligonucleotide
6/1/1999E-011-1997/06,238,858Transgenomic Viruses
2/1/1999E-113-1995/25,942,433
6,361,968
Extension Of A Protein-Protein Interaction Surface To Inactivate The Function Of A Cellular Protein
1/1/1999E-099-1990/05,474,935Adeno-Associated Virus (AAV)-Based Eucaryotic Vectors
12/1/1998E-066-1996/0AAV4 Vector And Uses Thereof
12/1/1998E-128-1998/0Use of Constitutive Transport Elements to Control the Host Range of Retroviral Vectors
8/1/1997E-011-1997/06,238,858Transgenic And Chimeric Viral Delivery Systems
1/1/1997E-093-1995/05,830,755T-Cell Receptors And Their Use In Therapeutic And Diagnostic Methods
4/1/1996E-169-1993/05,990,088Method For Treatment Of Kaposi's Sarcoma (KS) By Antisense Oligonucleotides
4/1/1996E-099-1994/0Avian Based Retrovirus Vectors
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